Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): A multicenter, non-blinded, randomized trial: Mohr J, Parides M, Stapf C, et al. Lancet 2014;383:614-21.

摘要

Unruptured brain arteriovenous malformations (AVM) pose a potentially lethal threat to patients if rupture were to occur. Currently, medical management alone and medical management with the addition of lesion eradication interventions are both viewed as acceptable management strategies in patients with unruptured AVMs. This nonblinded, multi-center, randomized control trial compared the outcomes of patients with unruptured AVMs who underwent medical management alone vs. both medical management and an intervention such as neurosur-gery, radiotherapy, embolization, or combination therapy.