A pharmacovigilance study for monitoring adverse drug reactions with antihypertensive agents at a South Delhi hospital

摘要

Objective: The aim of the present study was to conduct a pharmacovigilance study to monitor adverse drug reactions (ADRs) associated with antihypertensive drugs. Setting: The study was conducted in the medicine outpatient department of the 150-bedded Majeedia Hospital in South Delhi. Method: The study was conducted by a registered pharmacist by way of one-to-one patient interview by the pharmacist based on a questionnaire (ADR monitoring form) drafted according to World Health Organization (WHO) ADR monitoring guidelines. Key findings: A total of 22 ADRs were observed in 205 patients (95 males and 110 females) of mean age 49.6 ± 12 years and mean body mass index 25.7 ± 14.9 kg/m2. Out of 22 ADRs, 13 (59.1%) were mild, 8 (36.4%) were moderate and only 1 (4.5%) was classified as severe. Amlodipine was the drug associated with maximum ADRs (36.4%), followed by atenolol (13.6%), metoprolol and nevibilol (4.5% each). Conclusion: The above pharmacovigilance study presents the ADR profile of antihypertensive medicines prescribed in our university teaching hospital. Calcium channel blockers was the prescribed drug category associated with maximum ADRs, followed by beta-blockers, angiotensin-converting enzyme inhibitors and diuretics. 2006 The Authors.