首页> 外文期刊>Veterinary Parasitology >Comparative biochemical changes in young Zebu cattle experimentally infected with Trypanosoma vivax from tsetse infested and non-tsetse infested areas of northwest Ethiopia
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Comparative biochemical changes in young Zebu cattle experimentally infected with Trypanosoma vivax from tsetse infested and non-tsetse infested areas of northwest Ethiopia

机译:埃塞俄比亚西北部采采蝇侵染和非采采蝇侵染地区实验感染间日锥虫的成年牛的生化变化比较

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摘要

Trypanosomosis is a vector-borne protozoan disease of animals and humans in sub-Saharan Africa. In Ethiopia, particularly the northwest region is affected by both tsetse and non-tsetse transmitted trypanosomosis. The aim of the present study was to determine the effects and compare differences in virulence of Trypanosoma vivax infection between tsetse and non-tsetse infested areas of northwest Ethiopia on the basis of serum biochemical values in Zebu cattle. Eighteen cattles purchased from trypanosome free area and aged between 9 and 12 months were assigned into three groups of six animals (Group TT = infected with T. vivax from tsetse infested area, Group NT = infected with T. vivax from non-tsetse infested area and Group C = non-infected control). For each experimental animal 3ml of blood from naturally infected cattle was inoculated intravenously at 10(6) trypanosomes/ml except the control. Blood sample was collected once a week for 8 consecutive weeks for analyzing serum biochemical values (glucose, total cholesterol, total protein, albumin, and enzymes including GOT, GPT and ALP) using a Humastar 80 clinical chemistry analyzer. Both T. vivax parasites caused an acute infection with parasites appearing in circulation on 6 and 12 days post-infection for NT and IT cattle, respectively. A significant reduction (P 0.001) in glucose levels was observed in infected groups compared with the control with mean values of 33.8 +/- 3.6 mg/dl for TT, 34.3 +/- 3.6 mg/dl for NT and 70.9 +/- 3.0 mg/dl for control groups. A similar reduction was also seen in total cholesterol values (P = 0.001) with 70.4 +/- 10.6 mg/dl for TT and 78.0 +/- 10.6 mg/dl for NT groups compared to 139.5 +/- 8.7 mg/dl for the control group. No difference was observed for total serum protein between the three groups (P=0.260) whereas the mean albumin level was significantly (P 0.001) decreased (3.5 +/- 0.1 g/dl and 2.9 +/- 0.1 g/dl in TT and NT groups respectively) compared to that for control cattle (4.5 +/- 0.1 g/dl). On the other hand, infected groups had higher ALP values compared to the control (P = 0.007), with a mean value of 538.4 +/- 64.4 IU/L, 564.9 +/- 64.4 IU/L and 273.2 +/- 52.6 IU/L for TT, NT and control cattle, respectively. In conclusion, the two T. vivax parasites caused significant biochemical changes indicative of pathological responses. However, there was no significant variation between the two parasites in initiating these changes despite the difference in the onset of parasitaemia. (C) 2014 Elsevier B.V. All rights reserved.
机译:锥虫病是撒哈拉以南非洲地区的一种动物和人类媒介传播的原生动物疾病。在埃塞俄比亚,特别是采采蝇和非采采蝇传播的锥虫病都影响西北地区。本研究的目的是确定和比较埃塞俄比亚西北部采采蝇和非采采蝇感染地区之间的锥虫锥虫锥虫感染的毒力差异。从锥虫无核区购入的18头9至12个月大的牛分为三组,每组六只(TT组=采采蝇疫区感染间日疟原虫,NT组=非采采蝇疫区感染间日疟原虫。 C组=未感染对照)。对于每只实验动物,除对照组外,均以10(6)锥虫/ ml静脉接种3ml来自自然感染牛的血液。使用Humastar 80临床化学分析仪,每周连续8周每周收集一次血液样本,以分析血清生化值(葡萄糖,总胆固醇,总蛋白,白蛋白和酶,包括GOT,GPT和ALP)。两种间日疟原虫均引起急性感染,分别在NT和IT牛感染后6天和12天出现循环中出现的寄生虫。与对照组相比,感染组的血糖水平显着降低(P <0.001),TT平均值为33.8 +/- 3.6 mg / dl,NT平均值为34.3 +/- 3.6 mg / dl,70.9 +/-对照组为3.0 mg / dl。总胆固醇值(P = 0.001)也有类似的下降,TT组为70.4 +/- 10.6 mg / dl,NT组为78.0 +/- 10.6 mg / dl,而NT组为139.5 +/- 8.7 mg / dl。控制组。三组之间的总血清蛋白没有差异(P = 0.260),而平均白蛋白水平显着降低(P <0.001)(TT中为3.5 +/- 0.1 g / dl和2.9 +/- 0.1 g / dl)和NT组)与对照牛(4.5 +/- 0.1 g / dl)相比。另一方面,与对照组相比,感染组的ALP值更高(P = 0.007),平均值为538.4 +/- 64.4 IU / L,564.9 +/- 64.4 IU / L和273.2 +/- 52.6 IU / L分别代表TT,NT和对照牛。总之,两个间日疟原虫引起了明显的生化变化,表明病理反应。但是,尽管寄生虫病的发病率有所不同,但在引发这些变化时两种寄生虫之间并没有显着差异。 (C)2014 Elsevier B.V.保留所有权利。

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