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Colonisation and shedding of Lawsonia intracellularis in experimentally inoculated rodents and in wild rodents on pig farms

机译:猪场实验接种的啮齿动物和野生啮齿动物中胞内劳森菌的定殖和脱落

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Lawsonia intracellularis is an intracellular bacterium causing proliferative enteropathy in various animal species, and is considered an economically important pathogen of pigs. Rats and mice have been implicated as external vectors for a wide range of pig pathogens, including L. intracellularis. Previous studies have demonstrated L. intracellularis infection and proliferative enteropathy in rodents, but did not show the duration of shedding or the number of L intracellularis shed by infected rodents, and therefore the infection risk that rodents pose to pigs. In this study, the number of L. intracellularis shed in the faeces and intestinal mucosa of wild rats trapped on pig farms was determined by a quantitative real time polymerase chain reaction assay. The prevalence of L intracellularis in wild rats trapped on pig farms with endemic proliferative enteropathy (PE) was very high (>= 70.6%), and large numbers of L. intracellularis were shed (10(10)/g of faeces) in a small proportion of wild rats. The duration of colonisation in laboratory rats and mice challenged with porcine isolates of L intracellularis was also shown. Faecal shedding of L intracellularis persisted for 14-21 days in rats and mice that were mildly affected with histological lesions of PE. The humoral immune response to L intracellularis persisted for 40 days in both species.This study demonstrates that rodents may be an important reservoir of L intracellularis on piggeries, and hence rodent control is important in disease eradication programs on pig farms
机译:细胞内劳森菌是引起各种动物物种增生性肠病的细胞内细菌,被认为是猪的一种重要的经济病原体。已将大鼠和小鼠作为多种猪病原体(包括胞内劳森氏菌)的外部载体。先前的研究已经证明啮齿动物的胞内劳森氏菌感染和增生性肠病,但没有显示出被感染的啮齿动物的脱落持续时间或胞内L菌数量的减少,因此没有啮齿动物对猪造成的感染风险。在这项研究中,通过定量实时聚合酶链反应测定法确定了被困在猪场的野生大鼠的粪便和肠粘膜中脱落的胞内劳森氏菌的数量。在猪中,地方性增生性肠病(PE)困住的野大鼠中,细胞内L.的患病率很高(> = 70.6%),并且在猪场中有大量细胞内L.的脱落(10(10)/ g粪便)。野鼠的比例很小。还显示了在实验室大鼠和小鼠中被细胞内L猪分离株攻击后的定殖持续时间。在受到PE组织学损伤轻度影响的大鼠和小鼠中,胞内L菌的粪便排出持续14-21天。两种物种对细胞内L细胞的体液免疫反应持续了40天。这项研究表明,啮齿动物可能是猪体内细胞内L细胞的重要贮藏库,因此,啮齿动物的控制对养猪场的疾病消灭计划很重要。

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