The structure of the GRK2-Gbeta7 complex:intimate association of G-protein signaling modules

摘要

G-protein-mediated signaling is the most widely used signaling mechanism in cells and its regulation is crucial for various physiological functions. G-protein-coupled receptor (GPCR) kinases (GRKs) are involved in the desensitization of GPCR signals. Recently, the X-ray crystal structure of GRK2 complexed with G07 was demonstrated and revealed the intimate association of three important signaling modules with G(beta)_(gamma) to regulate GRK2 activity.