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首页> 外文期刊>Trends in Neurosciences >TiNS special issue: circuit development and remodeling.
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TiNS special issue: circuit development and remodeling.

机译:TiNS特刊:电路开发和重塑。

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摘要

Recently, we reported the properties of CD31-expressing cells in healthy individuals. However, the characteristics of CD31-expressing cells derived from coronary artery disease (CAD) patients remain unknown. This study aimed to investigate the relationship between circulating CD31(+) cells and CAD as well as their biological characteristics. Analysis with flow cytometry revealed that CD31(+) cells (C-CD31) from the peripheral blood (PB) of CAD patients exhibited low levels of T-cell marker and high levels of macrophage marker compared with the PB-CD31(+) cells from healthy individuals (H-CD31). In addition, the expression levels of multiple pro-angiogenic and chemokine genes were significantly down-regulated in C-CD31. However, inflammatory gene IL-1α was highly up-regulated in C-CD31. Patients with unstable angina (UA) had significantly more CD31(+) cells in the PB than healthy control group (P?
机译:最近,我们报道了健康个体中表达CD31的细胞的特性。但是,源自冠状动脉疾病(CAD)患者的CD31表达细胞的特征仍然未知。这项研究旨在调查循环的CD31(+)细胞与CAD之间的关系及其生物学特性。流式细胞仪分析显示,与PB-CD31(+)细胞相比,CAD患者外周血(PB)的CD31(+)细胞(C-CD31)表现出低水平的T细胞标志物和高水平的巨噬细胞标志物来自健康个体(H-CD31)。此外,C-CD31中多个促血管生成基因和趋化因子基因的表达水平显着下调。然而,炎症基因IL-1α在C-CD31中高度上调。不稳定型心绞痛(UA)患者的PB中CD31(+)细胞明显多于健康对照组(P <0.001)。而且,CD31 +细胞的数目与心血管疾病活动性之间有显着的相关性(R 2 = 0.318,P 2 = 0.006)和患病的冠状动脉的数目(R 3 = 0.312,P 2)。 =?0.005)。对于UA的诊断类别,曲线下面积为0.803(P <0.001)。总之,C-CD31损害了血管生成潜能,循环中的CD31(+)细胞数量与CV风险相关。这些发现可能有助于了解CAD的发病机理。

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