Calorie or carbohydrate restriction? The ketogenic diet as another option for supportive cancer treatment

摘要

In their recent article, "Nutrient Restriction and Radiation Therapy for Cancer Treatment: When Less is More" [1], Colin E. Champ and colleagues provide a good number of arguments why calorie restriction (CR), either through overall dietary reduction or through intermittent fasting, may be a potent supportive intervention for patients undergoing standard radiotherapy and/or chemotherapy. I strongly agree with the authors that CR targets so many important cancer survival pathway transducers at the same time that it should definitely be tested in clinical trials. However, I want to point out two main concerns about CR and possible strategies to address them.