The pharmacokinetics of cefepime in goats following single-dose i.v. and i.m. administration.

摘要

The pharmacokinetics of cefepime was studied in 5 goats following i.v. and i.m. administration of 10 mg/kg of body weight. Following i.v. administration, the cefepime plasma concentration-time curves were best fitted in a one-compartment open model. The elimination half-life (t_1/2 beta ), area under curve (AUC_{0-> infinity} ), and total body clearance (Cl_B) were 1.86+or-0.54 h, 181.58+or-80.52 micro g.h/mL, and 1.10+or-0.54 mL/min/kg, respectively. Following i.m. administration, pharmacokinetic parameters were analyzed using statistical moment theory (SMT). The drug was absorbed rapidly, with an absorption half-life (t_1/2abs) of 0.77+or-0.34 h. The peak plasma concentration (C_max) of 49.32+or-10.33 micro g/mL was attained after (T_max) 0.80+or-0.11 h, with an elimination half-life (t_1/2 beta ) of 1.65+or-0.38 h. The systemic bioavailability (F) of cefepime in the goats after i.m. administration was 86.45+or-17.39% and in vitro plasma protein binding was 7.45+or-4.46%. The dosage regime was estimated via the PK-PD relationship, considering the t value. The results suggest that cefepime was a potential bactericidal agent for more than 7 h by both administration routes, and that it might be very useful in the treatment of various infections in goats at 10 mg/kg of body weight administered i.v. or i.m. with 10 h as the dosage interval.