The RNA polymerase II preinitiation complexThrough what pathway is the complex assembled?

摘要

The general transcription factors required for the assembly of the RNA polymerase II preinitiation complex atTATA-depen-dent promoters are well known. However, recent studies point to two quite distinct pathways for assembly of these components into functional transcription complexes. In this review, the two pathways are compared and potential implications for gene regulatory mechanisms are discussed.