Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan.

摘要

An inhalation exposure study for particulate matter (PM) investigates links between exposure and observed changes in respiratory function by evaluating the interactions of chemical and physical properties of the PM with physiological mechanisms. Laboratory studies are useful in this regard, but provide limited information because of the difficulty in reproducing real atmospheric PM compositions and processes. To better understand the types of particles to which people are actually exposed in their daily lives, and the human health risks for source-specific PM, a real world assessment of the source-to-receptor pathways for ambient PM is vital. This was accomplished using a unique mobile air research laboratory (AirCARE1) which enables inhalation exposure studies in real-world settings. The overall goal of this study was to determine the effects of concentrated air particulates (CAPs) from 2 different urban atmospheres in Michigan on the lungs of ovalbumin-sensitized rats concurrently challenged with theallergen. Our work demonstrated that short-term (8 hours) exposure to ambient fine particulate matter (aerodynamic diameter