Chitosan-based films for the sustained release of peptides: A new era in buccal delivery?

摘要

In recent years, peptide-based drugs have received significant attention from researchers in academia as well as pharmaceutical and biotechnological industries. This has been fueled in part by the availability of recombinant technology, allowing high-throughput production of such therapeutic peptides. In 2012, six peptides were approved in the USA; five of which were also approved in the EU [1]. One of the most common peptide drugs is insulin, used in the treatment of diabetes. Another peptide carfilzomib is available to treat pituitary and gastrointestinal tumors and multiple myelomas [2,3].