A case report of the Modified Malmo Protocol: an alternative therapeutic approach to refractory chronic idiopathic thrombocytopenic purpura.

摘要

Therapy in refractory chronic idiopathic thrombocytopenic purpura is usually a difficult and expensive procedure, with little benefit to the patient, and the results are typically only short-term improvements. In this case report, we study a patient with refractory chronic idiopathic thrombocytopenic purpura who was initially treated with a first line therapy with only partial and temporary benefit, and in whom none of the experimental therapies tried later on resulted in any long lasting effect. In the case study conducted, among all the second-line experimental treatment modalities, only the proposed new protocol (the Modified Malmo Protocol) resulted in a major response. Our results suggest that, the Modified Malmo Protocol may be a promising second-line treatment option for severely refractory idiopathic thrombocytopenic purpura cases.