Tissue factor and factor VIIa: understanding the molecular mechanism.

摘要

Sitting at the apex of the clotting cascade, the tissue factor (TF): factor Vila (FVIIa) complex is essential for hemostasis and contributes to thrombosis. In addition to its hemostatic role, TF:FVIIa-dependent cleavage and activation of protease-activated receptor 2 (PAR2) is involved in tumor growth, angiogenesis and inflammation. This supplement explores new aspects of TF:Vlla biology in seventeen reviews divided into seven sections.