Obese individuals experience wheezing without asthma but not asthma without wheezing: a Mendelian randomisation study of 85 437 adults from the Copenhagen General Population Study

摘要

Background Observational studies suggest that obesity is associated with increased risk of asthma. However, it is unknown whether this could be explained by wheezing. We tested the hypothesis that high body mass index (BMI) observationally and genetically is associated with high risk of wheezing and asthma, and that the association between high BMI and asthma is explained by wheezing.