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Coarse particulate matter associated with increased risk of emergency hospital admissions for pneumonia in Hong Kong

机译:粗颗粒物与香港急诊入院的肺炎风险增加有关

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Background: Epidemiological research on the effects of coarse particles (PMc, particulate matter between 2.5 and 10 μm in aerodynamic diameter) on respiratory morbidity is sparse and inconclusive. Pneumonia is an inflammatory condition of lung caused by infections, which may be triggered and exacerbated by PMcexposure. Aim: To estimate the effect of PMcon emergency hospital admissions for pneumonia after controlling for PM2.5and gaseous pollutants. Method: PMcconcentrations were estimated by subtracting PM2.5from PM10measurements in each of the 10 air monitoring stations from January 2011 to December 2012 in Hong Kong and then citywide daily average concentrations of PMcwere computed from the 10 stations. Generalised additive Poisson models were used to examine the relationship between PMcand daily emergency hospital admissions for pneumonia, adjusting for PM2.5and gaseous pollutants (NO2, SO2and O3). Subgroup analyses by gender and age were also performed to identify the most susceptible subpopulations. Results: PMcand PM2.5were significantly associated with emergency pneumonia hospitalisations. Every 10 μg/m3increment of PMcin the past 4 days (lag0-lag3) was associated with a 3.33% (95% CI 1.54% to 5.15%) increase in emergency hospitalisations for pneumonia. The effect estimates of PMcwere robust to the adjustment of PM2.5, NO2or SO2, but attenuated on the inclusion of O3in the model. Women, children and older people might be more vulnerable to PMcexposure. Conclusions: Short-term PMcexposure is associated with emergency hospitalisations for pneumonia in Hong Kong. Air quality regulation specifically for PMcmight be considered.
机译:背景:关于粗颗粒(PMc,空气动力学直径在2.5到10μm之间的颗粒物)对呼吸道疾病的影响的流行病学研究很少而且尚无定论。肺炎是由感染引起的肺部炎症,可能由PMc暴露引起并加重。目的:评估控制PM2.5和气态污染物后PMcon急诊入院治疗肺炎的效果。方法:通过从2011年1月至2012年12月在香港的10个空气监测站中的每个PM10测量值中减去PM2.5来估算PMc浓度,然后从这10个监测站​​中计算出全市的PMc日平均浓度。使用广义加性泊松模型检查PMcand每日急诊入院肺炎,调整PM2.5与气态污染物(NO2,SO2和O3)之间的关系。还按性别和年龄进行了亚组分析,以确定最易感的亚人群。结果:PMcand PM2.5与紧急肺炎住院显着相关。在过去4天中,每增加10μg/ m3 PMcin(lag0-lag3),肺炎的紧急住院率就会增加3.33%(95%CI为1.54%至5.15%)。 PMc的效果估计值对PM2.5,NO2或SO2的调节具有鲁棒性,但在模型中包含O3时减弱。妇女,儿童和老年人可能更容易遭受PMcexposure。结论:短期PMc暴露与香港肺炎的紧急住院治疗有关。考虑专门针对PMcmight的空气质量法规。

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