Beta-blocker combinations for raised BP questioned

摘要

Serious doubts have been raised over the use of beta-blocker and diuretic combinations in hypertension by data from a huge UK study.The trial,involving almost 20,000 patients,compared a newer ACE inhibitor/calcium channel blocker combination with the more traditional combination.lt found the newer treatment strategy was associated with a 24 per cent relative risk reduction in cardiovascular mortality (P<0.0001).The older combination was also associated with a 32 per cent increased risk of developing diabetes (p<0001).