Metoclopramide,an antiemetic,effectively reduces headache pain associated with acute migraine and should be considered a primary treatment option in accident and emergency departments,say researchers (BMJ 2004;329:1369).They examined data from 13 randomised controlled trials,observing that as few as four patients need to be treated with the drug to enable one patient to achieve significant pain reduction.The researchers explain that meto-clopramide has long been used to treat nausea associated with migraine and that anecdotal reports have indicated it may also have analgesic properties.
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