Cognitive Function and Neurodevelopmental Outcomes in HIV-infected Children Older Than 1 Year of Age Randomized to Early Versus Deferred Antiretroviral Therapy: The PREDICTNeurodevelopmental Study

摘要

HIV afflicts greater than 3 million children worldwide1, yet our scientific understanding of the effects of timing of antiretroviral therapy (ART) on neurodevelopmental outcomes of these children is limited. Although ART decreases rates of encephalopathy, a most severe form of HTV-associated brain insult, chronic neurobehavioral deficits remain prevalent resulting in impairments in cognition, executive and adaptive functioning and school performance.2"9 Studies from developed and developing countries