An update on antimicrobial sensitivity testing for porcine E. coli and salmonella isolates including results from the UK archive with particular emphasis on colistin (Polymixin E).

摘要

Concerns that antimicrobial resistance in bacterial isolates of animal origin may lead to similar resistance in bacterial isolates of human health significance have been raised for several years (de Jong et al., 2009). This was highlighted by a recent intervention of the Chief Medical Officer, who stated that fluoroquinolones and third/fourth generation cephalosporins should be withdrawn from use in animals (Donaldson, 2008). Attention often focuses on the pig and poultry industries in this regard as high throughputs and relatively intensive production sometimes means that levels of antimicrobial use exceed those for other sectors. A recent British Veterinary Association (BVA) poster sets out the practical guidelines for dealing with these concerns (Anon, 2009). Enterobacteriacae are among the bacterial species commonly reported as showing antimicrobial resistance, and two members of this group, Escherichia coli and salmonella, are frequently targeted for therapeutic use of antimicrobials on UK pig units. This paper was, therefore, intended to give an update on the position, based on a review of literature and results of antimicrobial sensitivity testing on a sample of E. coli isolates associated with porcine enteric disease.