The Relationship Between Perineural Invasion, Tumor Grade, Reactive Stroma, and Prostate Cancer-Specific Mortality: A Clinicopathologic Study on a Population-Based Cohort

摘要

BACKGROUND. In vitro and in vivo studies have shown that nerves, tumor epithelium, and stroma interact and promote prostate cancer (PC) progression. Perineural invasion (PNI) is established amidst these interactions and may therefore indicate an aggressive PC phenotype. The purpose of the present study was to determine the relationship between PNI, tumor grade, reactive stroma, and PC-specific mortality.