Rebuttal from Jens Jordan

摘要

The new interventional treatments discussed in this CrossTalk debate address fundamental physiological mechanisms regulating autonomic nervous system activity and blood pressure, namely renal innervation, peripheral chemo-receptors, or carotid baroreflexes. The solid physiological rationale behind catheter-based renal denervation (Ratcliffe et al. 2014) and carotid chemoreceptor denervation/modulation (Schlaich et al. 2014) has been reviewed by a group of internationally recognized experts in the field. There is not much I could add. I would argue that catheter-based renal denervation, carotid chemoreceptor denervation/modulation and electrical carotid sinus stimulation deserved to undergo rigorous clinical testing. However, the road from a good idea to an effective treatment that can be incorporated into routine clinical care is a long one.