Assessing cardio-renal function in zebrafish larvae

摘要

The larva of the Zebrafish (Danio rerio) has become a leading model in various fields of physiology (e.g. Panula, 2010; Leong et al. 2010) and in developmental physiology (Grunwald &Eisen, 2002; Zetterberg, 2011). It is now possible to track gene expression with imaging methods and thereby gain detailed understanding of organ function in an intact vertebrate. In a recent issue of The Journal of Physiology, Rider etal. (2012) demonstrate this physiological application to better assess renal function.