Vasomotion and insulin-mediated capillary recruitment--part of the explanation?

摘要

In the 1990s, Baron and colleagues were among the first to report that insulin dilated resistance vessels and increased skeletal muscle blood flow. They further suggested that a defect in insulin's action to increase blood flow to insulin-sensitive tissues contributed to insulin resistance (Baron et al. 2000). More recently it has been shown that insulin increases microvascular perfusion in skin and skeletal muscle, and that impairment of insulin-mediated microvascular dilator responses in skeletal muscle decreases glucose uptake.