Input-output plasticity of peripheral responses in cerebellar Golgi cells in vivo.

摘要

In this issue of The Journal of Physiology, Xu & Edgley (2008) report on the induction of plastic changes in the response to peripheral stimulation in one of the major cerebellar cortical neurons, the Golgi cell. The response plasticity is induced by peripheral stimulation in combination with climbing fibre activation, but not by the same peripheral stimulation alone. Hence, this is a new form of climbing fibre-dependent cerebellar plasticity, which adds to the previously described long-term depression of parallel fibre input to Purkinje cells (Ito, 2006) and long-term potentiation of parallel fibre input to molecular layer interneurons (Jorntell & Ekerot, 2003; Rancillac & Crepel, 2004; Ito, 2006).