Understanding the role of voltage gating of polymodal TRP channels

摘要

Being able to sense multiple stimuli is a common feature of many transient receptor potential (TRP) channels and is in line with their proposed role in monitoring environment and body conditions. TRPV1 is well known for this polymodal regulation, being activated by noxious heat, acid, capsaicin and a number of cellular mechanisms. Among them, voltage gating has attracted much attention among channel biophysicists and physiologists alike. However, understanding the role of voltage on the overall gating mechanism of TRP channels has stirred some controversy