Effect of timing of chronic preoperative aspirin discontinuation on morbidity and mortality in patients having combined coronary artery bypass grafting and valve surgery

摘要

We read with interest the study by Jacob et al. Its objective was to determine if late use of aspirin before coronary artery bypass grafting (CABG) with valve surgery affects bleeding events and major adverse cardiovascular events. For preoperative aspirin administration, patients were divided in 2 groups: the "early-discontinuation" group had aspirin withdrawal >=6 days before surgery and the "late-use" group continued aspirin administration within 5 days of surgery. Lack of data concerning an objective quantification of the antiplatelet effect of aspirin constitutes a major drawback of the study. Expected inhibition of platelet function is not always achieved after aspirin administration.