AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition.

摘要

Osteoarthritis results from an imbalance between the breakdown and repair of articular cartilage in any joint and occurs as a result of multiple risk factors, including trauma, overuse, and genetic predisposition. Osteoarthritis (of any joint) was the primary diagnosis that led to 11.3 million ambulatory care visits in 2009. The Centers for Disease Control report that one in two individuals may develop symptoms of osteoarthritis in at least one knee by age 85 years. The annual incidence of knee osteoarthritis in the United States is estimated at 240 persons per 100,000.