Is weight loss an effective strategy to decrease serum uric acid levels without use of antihyperuricemic medications?

摘要

In their study of 1185 women and 1968 men, each of whom underwent 2 general health screening visits about 1 year apart, Ishizaka and colleagues report that percentage change in body mass index (%dBMI) is a predictor of the percentage change in uric acid levels (%dUA) in men and postmenopausal women, but not in premenopausal women1. As none of the patients was taking drugs to treat hyperuricemia at either visit, the authors conclude that "weight loss may represent an effective strategy to decrease serum UA levels without use of antihyperuricemic medications, especially in postmenopausal women and men." The basis for this conclusion is questionable in light of the slope estimates relating %dBMI to %dUA.