首页> 外文期刊>The Netherlands journal of medicine. >spase activation and the inhibition of Bfl-1 expression, all of which were blocked by the antioxidant, N-acetyl-L-cysteine (NAC). Moreover, addition of ceramide rescued the NAC-inhibited MAPK activation and pretreatment with the ceramide synthase inhibitor, fumonisin B1, reduced cell death. CONCLUSION: Our results suggest that in DU-145 prostate cancer cells: (i) EGCG+ibuprofen treatment has a synergistic effect on apoptosis, and (ii) oxidative stress, directly or indirectly via ceramide synthes
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spase activation and the inhibition of Bfl-1 expression, all of which were blocked by the antioxidant, N-acetyl-L-cysteine (NAC). Moreover, addition of ceramide rescued the NAC-inhibited MAPK activation and pretreatment with the ceramide synthase inhibitor, fumonisin B1, reduced cell death. CONCLUSION: Our results suggest that in DU-145 prostate cancer cells: (i) EGCG+ibuprofen treatment has a synergistic effect on apoptosis, and (ii) oxidative stress, directly or indirectly via ceramide synthes

机译:蛋白酶激活和Bfl-1表达的抑制,所有这些都被抗氧化剂N-乙酰基-L-半胱氨酸(NAC)阻断。此外,添加神经酰胺可挽救NAC抑制的MAPK活化,并用神经酰胺合酶抑制剂伏马菌素B1预处理可减少细胞死亡。结论:我们的结果表明,在DU-145前列腺癌细胞中:(i)EGCG +布洛芬治疗对细胞凋亡具有协同作用,并且(ii)通过神经酰胺合成直接或间接地产生氧化应激。

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