Bidentate P, N-P ligand for nickel-catalyzed cross-coupling of aryl or benzyl chlorides with ArMgX

摘要

A cross-coupling reaction of a variety of aryl, heteroaryl, and benzyl chlorides with ArMgX is catalyzed by 2 mol % of a nickel-phosphine complex prepared in situ from an equimolar amount of Ni(CH_3CN) _2Cl_2 and ligand (L2) to yield products in excellent yield in THF at room temperature. This new bidentate ligand (L2) is stable in air and forms a stable complex upon reaction with Ni(CH_3CN) _2Cl_2. Structures of the ligand and the complex were confirmed by single-crystal X-ray diffraction.