Four-component domino reaction providing an easy access to multifunctionalized tricyclo[6.2.2.0~(1,6)]dodecane derivatives

摘要

A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs _2CO_3 in ethylene glycol under microwave heating. The reaction proceeds at fast rates and can be finished within 15-24 min, which makes workup convenient. Four stereogenic centers with one quaternary carbon-amino function have been controlled completely. The stereochemistry has been unequivocally determined by X-ray structural analysis. The resulting tricyclo[6.2.2.0~(1,6)]dodecane derivatives are of importance for organic and medicinal research.