Zinc Chloride-Promoted Aryl Bromide—Alkyne Cross-Coupling Reactions at Room Temperature

摘要

Substoichiometric amounts of ZnCl_2 promote the roomtemperature, Pd/P(t-Bu)_3-catalyzed cross-coupling ofaryl bromides with alkynes. Pd(I) dimer 1 is demonstratedto be a particularly active precatalyst for this reaction.The reaction is general for a wide variety of aryl bromides.