Vanadium-Catalyzed. Asymmetric Epoxidation of Allylic Alcohols in Water

摘要

Asymmetric V-catalyzed epoxidation of allylic alcohols can be carried out in water with chiral ligands,which incorporate sulfonamide and hydroxamic acid fragments. Furthermore, the reaction, notorious forits ligand-deceleration effect, in water turned into the ligand-accelerated process. By using this aqueousprotocol, a range of allylic alcohols were epoxidized with up to 94% ee.