Synthesis of alpha-CF2-mannosides and their conversion to fluorinated pseudoglycopeptides

摘要

A methodology allowing the synthesis alpha-CF2-rnannosides, based on the addition of a difluoroenoxysilane to a glycal followed by a dihydroxylation reaction, is described. The resulting 2,2-difluoro-2-mannosylacetate is converted into two pseudoglycopeptides which may act as E- and P-selectin inhibitors.