Chiral Diols:A New Class of Additives for Direct Aldol Reaction Catalyzed by L-Proline

摘要

Nine C_2 symmetric diols have been examined as additives in the L-proline-catalyzed direct aldol reaction with significant improvement in enantioselectivity,conversion efficiency,and yield.Loading of 1 mol % of (S)-BINOL leads to the desired products in up to 98% ee and 90% yield.A transition state is proposed.