Quantum chemical study of diels-alder reactions catalyzed by lewis acid activated oxazaborolidines

摘要

The catalytic activity of Lewis acid activated oxazaborolidines in the Diels-Alder reaction between cyclopentadiene and methacrolein is investigated by using the DFT method. Oxazaborolidine is not able to coordinate to methacrolein in the absence of AlBr_3 because the bonding stabilization is too small to cover the destabilization arising from the deformation of the two species. Accordingly, oxazaborolidine hardly catalyzes the cycloaddition by itself. The calculations show that the attachment of AlBr_3 to the nitrogen atom of oxazaborolidine enhances the Lewis acidity of its boron center and enables it to coordinate to methacrolein. When the AlBr_3-assisted oxazaborolidine is once coordinated, the catalytic activity originates mainly from the oxazaborolidine framework, and to a smaller extent from the attached AlBr_3 part. The Lewis acid AlBr_3 plays an additional role to facilitate the reaction by reducing the overlap repulsion between the diene and the dienophile. The attachment of AlBr_3 to the oxygen atom, another Lewis basic site in oxazaborolidine, also gives a stable AlBr _3-oxazaborolidine complex, but the reaction catalyzed by this complex is not preferred to that catalyzed by the complex in which AlBr_3 is attached to the nitrogen atom. The electrophilicity of boron center in oxazaborolidine and those in the AlBr_3-oxazaborolidine complexes are compared in terms of localized reactive orbitals.