Copper(I)-catalyzed cascade sulfonimidate to sulfonamide rearrangement: Synthesis of imidazo[1,2-a][1,4]diazepin-7(6 H)-one

摘要

A novel strategy of copper(I)-catalyzed cascade intramolecular nucleophilic attack on N-sulfonylketenimine followed by rearrangement of sulfonimidates to sulfonamides resulting in a library of substituted 8,9-dihydro-5H-imidazo[1,2-a] [1,4]diazepin-7(6H)-ones has been developed.