Copper(I)-Catalyzed Cascade Sulfonimidate to Sulfonamide Rearrangement: Synthesis of Imidazo[1,2-a][1,4]diazepin-7(6H)-one

摘要

A novel strategy of copper(I)-catalyzed cascade intramolecular nucleophilic attack on N-sulfonylketeniminenfollowed by rearrangement of sulfonimidates to sulfonamides resulting in a library of substituted 8,9-dihydro-5H-imidazo[1,2-a]-n[1,4]diazepin-7(6H)-ones has been developed.