Biologically active metabolites of the facultative marine fungus Penicillium citrinum

摘要

Four sesquiterpenoid metabolites, JBIR-27, petasol, sporogen AO-1, and dihydrosporogen AO-1, that were previously unknown for Penicillium citrinum were isolated from the marine isolate of this fungus. The structures of the compounds were established using NMR spectral data and high-resolution mass spectrometry. It was shown that sporogen AO-1 exhibited weak antimicrobial and cytotoxic properties. Cytotoxic action was observed for dihydrosporogen AO-1 against Ehrlich carcinoma cells (ED_(50) 0.4 mM).