Comments on 'Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1,and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel'

摘要

Shi et al.(2006)conclude in their recent article that,because clopidogrel inhibits the hydrolysis and therefore the activation of oseltamivir,the concurrent use of these drugs would render the latter therapeutically inactive.In reaching their conclusions,we believe that the authors have extrapolated their findings beyond the scope of the study and have addressed neither the limitations of their in vitro dataset nor the clinical relevance of the drug concentrations evaluated,as illustrated below.