Blame Vaccine Interference, Not Neonatal Immunization, for Suboptimal Responses after Neonatal Diphtheria, Tetanus, and Acellular Pertussis Immunization

摘要

Defining which mechanisms interfere with vaccine antibody responses after neonatal DTaP immunization may only be hypothesis driven, because cellular responses were not measured by Halasa et al. Such interferences were not observed in infants immunized neonatally with 2 other acellular pertussis vaccines. This could reflect differences in formulations, including a potential role of the adjuvant (aluminum hydroxide in GSK and Novartis vaccines, aluminum phosphate in Daptacel), known to affect pertussis vaccine immu-nogenicity and efficacy.