Vigabatrin-Relatecl Magnetic Resonance imaging Abnormalities in an Infant with Tuberous Sclerosis Complex and Infantile Spasms

摘要

Anewborn with hypopigmented skin macules, cardiac rhabdomyomas, and cerebral magnetic resonance imaging (MRI) demonstrating cortical tubers and sube-pendymal nodules (Figure, A) was diagnosed with tuberous sclerosis complex (TSC). Clusters of flexor spasms began at 3 months of age, infantile spasms was diagnosed. Treatment was commenced with vigabatrin, an irreversible inhibitor of y-aminobutyric acid transaminase, and the spasms ceased within 1 week. Routine follow-up MRI demonstrated the interval development of asymptomatic abnormalities, including restricted diffusion in the bilateral brainstem, basal ganglia, and thalami (Figure, B). After 1 year of successful treatment, the vigabatrin was discontinued and follow-up MRI demonstrated full resolution of these abnormalities (Figure, C).