Trade-off between lower or higher oxygen saturations for extremely preterm infants: The first benefits of oxygen saturation targeting (BOOST) ii trial reports its primary outcome

摘要

Administration of supplemental oxygen to very preterm i nfants is exacting because clinicians must strike a fine balance between the competing risks of insufficient oxygen delivery to the tissues and oxygen-induced damage to multiple organs including the eye, lung, and brain. The range of oxygen saturations that will best accomplish this goal is uncertain. To address this knowledge gap, 5 randomized trials were initiated between 2005 and 2007 to compare oxygen saturation target ranges of 85%-89% vs 91%-95% by continuous pulse oximetry. These 2 narrow ranges were chosen because they were within the "pragmatically determined" and commonly accepted wider range of 85%-95%. The different study teams discussed important aspects of the trial protocols such as target populations, study oximeters, saturation targets, sample sizes, and primary outcomes during several planning meetings and agreed to perform an individual patient data meta-analysis after the completion and publication of all 5 trials. However, each of the 5 trials was individually designed and managed.