In the normal mammalian brain, neuronal synchrony occurs on a spatial scale of submillimeters to centimeters and temporal scale of submilliseconds to seconds that is reflected in the occurrence of high-frequency oscillations, physiological sharp waves and slow wave sleep oscillations referred to as Up-Down states. In the epileptic brain, the well-studied pathologic counterparts to these physiological events are pathological high-frequency oscillations and interictal spikes that could be electrophysiological biomarkers of epilepsy. Establishing these abnormal events as biomarkers of epilepsy will largely depend on a better understanding of the mechanisms underlying their generation, which will not only help distinguish pathological from physiological events, but will also determine what roles these pathological events play in epileptogenesis and epileptogenicity. This article focuses on the properties and neuronal mechanisms supporting the generation of high-frequency oscillations and interictal spikes, and introduces a new phenomenon called Up-spikes.
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