99mTc-MAA-based dosimetry for liver cancer treated using 90Y-loaded microspheres: Known proof of effectiveness

摘要

TO THE EDITOR: It was with great interest that we read the study by Lam et al. entitled "Prognostic Utility of 90Y Radio-embolization Dosimetry Based on Fusion 99mTc-Macroaggre-gated Albumin-99mTc-Sulfur Colloid SPECT," published in December 2013 (7). In this paper, the authors described an original method based on 99mTc-macroaggregated albumin (99mTc-MAA) and 99mTc-sulfur colloid (99mTc-SC) SPECT to be used for segmentation between tumors and healthy liver tissue in the context of liver metastases. Mean tumor and healthy-liver doses were then calculated using the MIRD formalism. The study findings revealed a strong correlation between tumor dose and both response to 90Y-loaded resin microspheres and survival in a cohort of patients with liver metastases treated using 90Y-loaded resin microspheres. Several questions or comments can be raised in response to this publication.