Comparison of Efficacy and Tolerability of HylanG-F 20 in Patients with and without Effusions atthe Time of Initial Injection

摘要

An effusion at the onset of viscosupplementation has been thought to diminish the efficacyand increase adverse event rates. This study compares efficacy of hylan G-F 20 in patientswith and without an effusion. Patients with knee osteoarthritis (OA) received three weeklyinjections of hylan G-F 20. A total of 50 patients with an effusion requiring aspiration werecompared with 50 matched patients without an effusion. Outcome measurementsincluded Western Ontario and McMaster's Universities Osteoarthritis index (WOMAC)and visual analog scale (VAS). Patients were followed for 26 weeks. Both effusion andcontrol group VAS was significantly lowered at all time points. WOMAC scores improved(p < 0.025) at all visits in the effusion group except for WOMAC A-1 week 14. ControlWOMAC scores also significantly improved at all visits (p < 0.027), except for full WOMACand WOMAC A-1 at week 1. Neither group experienced an adverse event. Presence of aneffusion at onset of viscosupplementation requiring aspiration does not negatively impactefficacy of hylan G-F 20 or increase adverse event rates.