Differential IgG recognition of desmoglein 3 by paraneoplastic pemphigus and pemphigus vulgaris sera

摘要

Paraneoplastic pemphigus (PNP) is a frequently lethal autoimmune bullous disease characterized by severe polymorphous mucocutaneous lesions and is commonly associated with hematologic malignancies, particularly non-Hodgkin lymphomas, chronic lymphatic leukemia, and Castleman's disease (Anhalt, 2004). The autoantibody profile of PNP is less restricted and includes recognition of the autoanti-gens of pemphigus vulgaris (PV), pemphigus foliaceus (PF), and bullous pemphigoid (BP).