Increased severity of 2009 pandemic influenza A virus subtype H1N1 infection in alveolar type II cells from patients with pulmonary fibrosis.

摘要

Weinheimer et al [1] reported that influenza A viruses preferentially infect alveolar epithelial type II (ATII) cells in lung tissue explants and suggested that the pathogenicity of influenza A viruses is associated with the ability of these viruses to replicate in ATII cells and induce the production of inflammatory cytokines. In contrast, an epi-demiological study by Nguyen-Van-Tam et al [2] demonstrated that chronic pulmonary comorbidities such as pulmonary fibrosis were risk factors for poor outcomes for 2009 pandemic influenza A virus subtype H1N1 (A[HlNl]pdmO9) infection.