One-step synthesis of the vicinal dinitroguaianolides achillin and grossmisin

摘要

1,10-Dihydro-1α,10α-dinitrogrossmisin was synthesized by bubbling gaseous nitrosyl chloride through a chloroform solution of the guaianolide grossmisin. The molecular structure was determined by X-ray. It was found that the formation of similar dinitrates is accelerated by using NOCl containing nitrogen dioxide.