Indirect resistance to several classes of antibiotics in cocultures with resistant bacteria expressing antibiotic-modifying or -degrading enzymes

摘要

Objectives: The detection of indirect resistance in vitro suggests that coinfecting bacteria from the normal microbial flora may have a more important negative impact during antimicrobial therapy than is generally appreciated.Indirect resistance (IR), the ability of an antibiotic-resistant population of bacteria to protect a susceptible population, has been previously observed for beta-lactamase-producing bacteria and associated with antimicrobial treatment failures. Here, we determined whether other resistance determinants could cause IR in the presence of five other classes of antibiotics.